Okay, so the game isn't groundbreaking in the story department. But it would make a pretty decent horror movie if it was done right. The movie, however, can't help but the present the argument 'Why call it Resident Evil?'. If you desire to make a film about an amnesiac female hero and rogue computers and zombies, then go do it. The game didn't invent the concept of motherfucking zombies so there's no reason to remain loyal to it's name.
Which brings me back to Silent Hill. The game series has had its ups and down in terms of story, but there was a few nuggets of absolute gold in there. So if you were enticed enough to make a movie out of it, what's the point in changing it? It's like making a Lord Of The Rings movie with robots, space monsters and Martin Lawrence and just throwing in a few Hobbits to please the fans.